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Baclofen is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by medical problems, including multiple sclerosis or certain injuries to the spine. Baclofen does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

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How does Baclofen work ?

Baclofen acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine’s side effects. Baclofen may also be used to relieve other conditions as determined by your doctor.

Baclofen (beta-[4-chlorophenyl]-GABA) is an agonist at the beta subunit of gamma-aminobutyric acid on mono and polysynaptic neurons at the spinal cord level and brain. The thinking is that baclofen reduces the release of excitatory neurotransmitters in the pre-synaptic neurons and stimulates inhibitory neuronal signals in the post-synaptic neurons with resultant relief of spasticity. Baclofen is also found to have an affinity for voltage-gated calcium channels. However, its clinical efficacy in this regard is still unclear.

Baclofen has a 70% to 85% bioavailability and is rapidly absorbed through the gastrointestinal tract following oral administration. Peak plasma concentrations are generally observed 2 to 3 hours after ingestion. The absorption is dose-dependent and increases with higher doses. Due to the short half-life of 2 to 6 hours, baclofen should be administrated frequently to achieve optimal effect.

Seventy percent of baclofen is eliminated in an unchanged form by renal excretion and the remaining via feces. Thereby, baclofen is a useful agent in patients with impaired hepatic function or a high potential for cytochrome P450-mediated drug-drug interactions. Research has observed significant inter-individual variability in baclofen’s absorption and elimination processes.

This medicine is available only with your doctor’s prescription.

This product is available in the following dosage forms:

- Tablet
- Solution
- Packet
- Suspension

Off-labeled Uses of Baclofen

- Baclofen is used off-label to manage alcoholic liver disease.
- Maintain alcohol abstinence by decreasing alcohol cravings and alcohol-related anxiety.
- Trigeminal neuralgia, gastroesophageal reflux disease, and hiccups.
- Baclofen is also considered for short-term treatment for spasticity associated with cerebral palsy in children and adolescents.

Baclofen is not recommended for use in patients with Parkinson disease and stroke due to a lack of reassuring data. In addition, baclofen is not indicated for skeletal muscle spasms associated with rheumatologic disorders.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of baclofen oral liquid and granules in children younger than 12 years of age. Safety and efficacy have not been established.

Appropriate studies have not been performed on the relationship of age to the effects of baclofen tablets in the pediatric population. Safety and efficacy have not been established..

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of baclofen oral liquid and granules in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution for patients receiving this medicine.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of baclofen tablet in the elderly. Side effects such as hallucinations, confusion or mental depression, other mood or mental changes, and severe drowsiness may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of this medicine.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

- - Alfentanil
  - Alprazolam
  - Amifampridine
  - Benzhydrocodone
  - Bromazepam
  - Buprenorphine
  - Bupropion
  - Butorphanol
  - Calcium Oxybate
  - Cannabidiol
  - Cetirizine
  - Clobazam
  - Clonazepam
  - Codeine
  - Daridorexant
  - Dexmedetomidine
  - Dihydrocodeine
  - Donepezil
  - Doxylamine
  - Esketamine
  - Fentanyl
  - Flibanserin
  - Gabapentin
  - Gabapentin Enacarbil
  - Hydrocodone
  - Hydromorphone
  - Ketamine
  - Lemborexant
  - Levocetirizine
  - Levorphanol
  - Lofexidine
  - Loxapine
  - Magnesium Oxybate
  - Meperidine
  - Methadone
  - Metoclopramide
  - Midazolam
  - Morphine
  - Morphine Sulfate Liposome
  - Nalbuphine
  - Oxycodone
  - Oxymorphone
  - Pentazocine
  - Periciazine
  - Potassium Oxybate
  - Pregabalin
  - Remifentanil
  - Remimazolam
  - Ropeginterferon Alfa-2b-njft
  - Scopolamine
  - Sodium Oxybate
  - Sufentanil
  - Tapentadol
  - Tramadol
  - Trazodone
  - Zolpidem

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, or do not take it longer than your doctor ordered.

This medicine comes with a patient information and instructions leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

To use the granules:

- - Open the packet and empty all the granules directly into your mouth. The granules will dissolve in your mouth or can be swallowed. You may drink water after taking the medicine.
  - You may mix the granules with 1 tablespoon (15 mL) of liquid (eg, apple juice or milk) or soft foods (eg, applesauce, pudding, or yogurt). Take this mixture within 2 hours of mixing.
  - This medicine can also be given using a nasogastric or gastric feeding tube. Mix the granules with 1 tablespoon (15 mL) of liquid (eg, apple juice or milk). Give this mixture within 2 hours of mixing. After the medicine is given, flush the tube with an additional 1 tablespoon (15 mL) of water.
  - Take all the contents of the packet to get a full dose. Do not take only part of this medicine. Do not save a portion for later use.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For muscle relaxation:
- For oral dosage form (granules):
  - Adults and children 12 years of age and older—At first, 5 milligrams (mg) 3 times a day for 3 days. Your doctor may increase your dose by 5 mg every 3 days as needed and tolerated. However, the dose is usually not more than 80 milligrams (mg) per day (20 mg four times a day).
  - Children younger than 12 years of age—Use and dose must be determined by your doctor.
- For oral dosage form (solution):
  - Adults and children 12 years of age and older—At first, 5 milliliters (mL) 3 times a day for 3 days. Your doctor may increase your dose by 5 mL every 3 days as needed and tolerated. However, the dose is usually not more than 80 milligrams (mg) per day (20 mg four times a day).
  - Children younger than 12 years of age—Use and dose must be determined by your doctor.
- For oral dosage form (tablets):
  - Adults and teenagers—At first, 5 milligrams (mg) 3 times a day. Your doctor may increase your dose by 5 mg every 3 days until the desired response is reached. However, the dose is not more than 80 mg per day.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the oral liquid in the refrigerator. Do not freeze.

Precautions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Do not suddenly stop using this medicine without checking first with your doctor. You may need to slowly decrease your dose before stopping it completely. Unwanted side effects (eg, hallucinations, seizures, high fever, rhabdomyolysis) may occur if baclofen is stopped suddenly.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, other muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using baclofen.

This medicine may cause dizziness, drowsiness, vision problems, or clumsiness or unsteadiness in some people. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert, well-coordinated, and able to see well.

This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

Using this medicine while you are pregnant may cause neonatal withdrawal syndrome in your newborn babies. Tell your doctor right away if your baby has shakiness or tremors, seizures, or increased muscle tone.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common or rare

1. Bloody or dark urine
2. chest pain
3. clumsiness, unsteadiness, trembling, or other problems with muscle control
4. fainting
5. false sense of well-being
6. mental depression or other mood changes
7. pounding heartbeat
8. ringing or buzzing in the ears
9. seeing or hearing things that are not there
10. skin rash or itching
11. slurred speech or other speech problems
12. swelling of the ankles
13. unexplained muscle stiffness
14. unusual excitement

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

1. Blurred vision
2. dizziness
3. drowsiness
4. irregular, fast or slow, or shallow breathing
5. lightheadedness
6. loss of strength or energy
7. muscle pain or weakness
8. pale or blue lips, fingernails, or skin
9. seizures
10. sleepiness or unusual drowsiness
11. trouble breathing
12. unusual weak feeling

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

1. Confusion
2. constipation
3. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
4. headache
5. increased need to urinate
6. nausea
7. passing urine more often
8. sweating
9. trouble sleeping
10. unusual tiredness or weakness

Less common or rare

1. Diarrhea
2. loss of appetite
3. muscle or joint pain
4. numbness or tingling in the hands or feet
5. stomach pain or discomfort
6. stuffy nose
7. weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Baclofen Withdrawal Syndrome

Discontinuation of baclofen can be associated with a withdrawal syndrome which resembles benzodiazepine withdrawal and alcohol withdrawal. Withdrawal symptoms are more likely if baclofen is administered intrathecally or for long periods of time (more than a couple of months) and can occur from low or high doses.

The severity of baclofen withdrawal depends on the rate at which it is discontinued. Thus to minimise withdrawal symptoms, the dose should be tapered down slowly when discontinuing baclofen therapy. Abrupt withdrawal is more likely to result in severe withdrawal symptoms. Acute withdrawal symptoms can be eased or completely reversed by re-initiating therapy with baclofen.

Withdrawal symptoms may include auditory hallucinations, visual hallucinations, tactile hallucinations, delusions, confusion, agitation, delirium, disorientation, fluctuation of consciousness, insomnia, dizziness, nausea, inattention, memory impairments, perceptual disturbances, itching, anxiety, depersonalization, hypertonia, hyperthermia (higher than normal temperature without infection), formal thought disorder, psychosis, mania, mood disturbances, restlessness, and behavioral disturbances, tachycardia, seizures, tremors, autonomic dysfunction, hyperpyrexia (fever), extreme muscle rigidity resembling neuroleptic malignant syndrome and rebound spasticity.

Baclofen Abuse

Russian baclofen (trade name “Baclosan”) 25 mg tablets with a warning: “Caution: the drug may suppress psychomotor reactions”

Baclofen, at standard dosing, does not appear to possess addictive properties, and has not been associated with any degree of drug craving. Euphoria is however listed as a common to very common side-effect of baclofen in the BNF 75 There are very few cases of abuse of baclofen for reasons other than attempted suicide.

In contrast to baclofen, another GABAB receptor agonist, γ-hydroxybutyric acid (GHB), has been associated with euphoria, abuse, and addiction. These effects are likely mediated not by activation of the GABAB receptor, but rather by activation of the GHB receptor. Baclofen possesses both sedative and anxiolytic properties.

Toxicity of taking Baclofen

Overdose primarily arises from drug screening before pump implantation or human error during pump refilling and programming. Baclofen overdose may cause altered mental status, somnolence, seizure, hypothermia, respiratory depression, and coma. In the presence of overdose symptoms, the medical staff should empty the pump reservoir, and the patient should receive symptomatic management. In patients when the lumbar puncture is not contraindicated, consider withdrawing 30-40 mL of CSF to reduce baclofen CSF concentration.

Overdosed on baclofen tablets has reported vomiting, drowsiness, muscular hypotonia, accommodation disorders, coma, respiratory depression, and seizures. When the patient is alert, consider vacating the stomach immediately by inducing emesis and then performing lavage. In the unconscious patients, do not induce emesis. Before beginning lavage, secure the airway with an endotracheal tube. Avoid the use of respiratory stimulants and adequately maintain respiratory exchange.

One thought on “Buy Baclofen 20mg”

Fowbr01 says:

December 12, 2022 at 6:23 pm

For Muscle Spasm “I have only used baclofen for 3 weeks but I can say it is truly a miracle drug for me. I have suffered from chronic pain for 20 years after a motorcycle accident that resulted in fractures of T1 2 in 3 of my transverse processes and displacement of 2 other vertebras including 13 other fractures including punctured lungs and separations in my shoulder and clavicle. I know everybody on this post has serious pain. I tried every narcotic pain medication even becoming chemically dependent and eventually addicted to many of them and 4 other muscle relaxers and every other treatment (PT, acupuncture surgeries etc.) that I’m sure everybody on this board has tried. I have serious scar tissue in my upper back lower neck which caused me constant and severe pain. I stumbled upon baclofen going to urgent care to get a toradol shot just to make it so I could sleep that night. After I woke up the next morning taking my 1st dose of baclofen I had 50%+ pain reduction! For those of you that suffer from true chronic pain that is life affecting every minute of your life you can understand why I’m in tears writing this post. I cannot believe I had never tried this medication. I’m sure it does not work the same for everybody but when it works it is a miracle drug! I now can sleep the whole night and when I wake up in the morning I am not dreading a day of pain. Let me be clear I had 20 years of debilitating pain every minute I was awake unless I sedated myself so much that I could finally fall asleep. I went to four detox centers and two rehabs Because of all the opiate pain medications I was taking and then became addicted to. I have been suffering through taking naltrexone to keep me from using narcotic pain meds to escape from my pain. I have a whole new life at age 42 now. I pray that this medication works as well for anybody else reading or posting on this site. God bless all of you suffering.”

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